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Alprazolam, sold under the brand name Xanax, among others, is a short-acting tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring.[6] It is most commonly used in short-term management of anxiety disorders, specifically panic disorder or generalized anxiety disorder (GAD).[7] Other uses include the treatment of chemotherapy-induced nausea, together with other treatments.[5] GAD improvement occurs generally within a week.[8][9] Alprazolam is generally taken by mouth.[5]

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Common side effects include sleepiness, depression, headaches, feeling tired, dry mouth, and memory problems.[5] Some of the sedation and tiredness may improve within a few days.[10] Due to concerns about misuse, some do not recommend alprazolam as an initial treatment for panic disorder.[11] Withdrawal or rebound symptoms may occur if use is suddenly decreased;[5] gradually decreasing the dose over weeks or months may be required.[8] Other rare risks include suicide, possibly due to loss of inhibition.[12] Alprazolam, like other benzodiazepines, acts through the GABAA receptor.[5]

Alprazolam was patented in 1971 and approved for medical use in the United States in 1981.[5][13] Alprazolam is a Schedule IV controlled substance and is a common drug of abuse.[2][14] It is available as a generic medication.[7] In 2018, it was the 37th most commonly prescribed medication in the United States, with more than 20 million prescriptions.[15][16]

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